Mariana Bobeica, a Marie-Curie postdoctoral researcher at the Institute for Medical Science and Technology (IMSaT), University of Dundee is involved in the Nanoporation research project. She holds a BSc in Physics/Physics of Polymers from University of Bucharest, Romania, a MSc in Physics (2004) from SUNY Buffalo, USA and a PhD in Chemical Engineering (2009) from University of Rochester, Rochester, NY, USA.
Mariana started her research activity in 2001 when she received a fellowship in the Physics Department at the State University of New York at Buffalo, USA. At SUNY Buffalo Mariana completed a research project in delivery of high energy electron beams for cancer treatment in collaboration with Roswell Park Cancer Institute, Buffalo, NY. In 2004 she joined the Chemical Engineering Department at the University of Rochester, Rochester, NY and began PhD studies in the field of Fusion Technology at the Laboratory for Laser Energetics (LLE), Rochester, NY. In 2004-2005 she was awarded the F.J. Horton Fellowship. Her PhD thesis which was part of an extensive study (the HAPL program) with participants from many USA national research laboratories, was concerned with the heat transfer in solid deuterium sub -millimetre targets from a thermal background of the inertial fusion energy chamber (IFE chamber). Between 2009 and 2011 Mariana was a postdoctoral researcher at the Institute for Bio-Nanotechnology in Medicine (IBNAM) at Northwestern University, Chicago, IL where she worked on functionalized Au nanoparticles - biomimetic nanostructures and their medical applications as therapeutics in cardiovascular diseases and for genetic material delivery.
Mariana taught extensively Physics and occasionally Chemistry at a high school in Romania until 2001 and at SUNY Buffalo she had also the privilege to teach Physics as a Teaching Assistant/Lecturer between 2001 and 2004.
Her current research interests are mainly applications of Physics in various engineering fields, particularly in nanomedicine and bio-medical engineering such as therapeutics and diagnostics with functionalized nanoparticles and ultrasound-mediated drug delivery.
Role in the Nanoporation project
In the Nanoporation project Mariana has designed, built and optimised a high throughput device (sonicator) that allows FUS exposure during in-vitro experiments of cancerous cells, microbubbles, liposomes and various other types of nano-carriers for enhanced drug delivery and cell-poration. One of the projectís goals is to identify the FUS protocols for standardised in- vitro experiments and offer guidelines for future in-vivo experiments using the MRgFUS system (ExAblate).